However, the Belgium worldwide sustained an issue with his opposite knee during a coming together with Timothy Fosu-Mensah, and it has left the playmaker facing another spell on the sidelines.
De Bruyne is now likely to miss City's next six matches at least, including next Sunday's derby against Manchester United at the Etihad.
Earlier on Friday, sources had told ESPN FC that De Bruyne would miss the visit of Manchester United on November 11.
"I think today, Kevin is back", Guardiola said.
"We want him. But, in the end, it doesn't depend on us".
"We are a stronger team with Kevin than without him, but we have to live without him and we have to be there when he comes back".
While nobody wishes serious injury anybody, it is a testament to what a superb player De Bruyne is that fans of the other top six Premier League clubs will see his injury as a glimmer of hope as they try keep pace with Guardiola's hugely impressive side. Asked if he was anxious about the injury, Guardiola said, "I don't know right now".
He will definitely be out of City's next two games, against Southampton on Sunday and Shakhtar Donetsk on Wednesday, though he will be helped by the November global break following the derby.
"And maybe that is going to help us in the last part of the season - he will be fresh and his body and help us reach our targets".
It means De Bruyne will certainly miss next weekend's showdown with Manchester United, while he is a doubt to be available to face Premier League title rivals Chelsea on December 8.