If Tottenham boss Mauricio Pochettino thought Wednesday's match in Eindhoven was not a "must win" match, he'll certainly think differently about his club's next match in the Champions League against PSV in London on November 6.
But Spurs were reduced to 10 men for the last 10 minutes after Lloris was sent off for a foul on Lozano. The resulting free-kick saw De Jong aim for the bottom corner but Michel Vorm got down to make the save.
"In the end (it was) a draw and (it leaves us) with the minimum possibility to go to the next stage of the Champions League", Pochettino told BT Sport.
"Today was a game completely dominated by us but we needed to be more aggressive and score more than twice".
He also has this to say about the red card his team got in the game: "In my opinion I think no, but we can not blame the referee". It went against us but we should have finished the game off - we made it hard for ourselves. The ball looped over a hapless Hugo Lloris after Alderweireld looked to have atoned for his error with a last-ditch tackle, only for the ball to deflect into the back of the net.
Kieran Trippier cut a cross back to Moura near the penalty spot, and the Brazilian swept the ball up with his right foot and watched as it bounded over a helpless Jeroen Zost in goal to draw Spurs level in the 39th minute.
While there is certainly a case to be made that the English striker was in no way interfering with play, there is little question that he was in an offside position.
Tottenham were thankful moments later when Pereiro dribbled past Alderweireld to prod an effort off Lloris's bar.
Lloris was given a straight red card after racing out of his goal and scything down Lozano, and Spurs were unable to survive the loss of their captain, with De Jong prodding home Pablo Rosario's mishit shot.
Tottenham started on top and had the better chances in the opening stages, with Harry Kane hitting the bar, while PSV only caused danger through free-kicks.
"He had a good World Cup, he's been a terrific keeper for Spurs but there has been more mistakes this season for some reason".