Authorities have confirmed those storm-related deaths, including a mother and her infant child who died after a tree fell on their home in New Hanover County, where the storm hit Friday morning with a 105 miles per hour wind gust, the strongest wind in the city since 1958.
Wilmington police tweeted that the father was transported to the hospital with unspecified injuries.
She went to say that she did not start to get anxious until about 3 a.m. when the power went out and she wasn't able to get the generator restarted.
EMS services could not get to the woman due to the storm, marking the third Florence-related death since the storm began hitting the North Carolina coastline.
Tropical-storm-force winds extend up to 175 miles from the center of the storm.
Jennifer Morales, 20, said there was 3 feet of water in her home.
"We are saddened by the sudden passing of one of our community, and our hearts go out to the family and friends who are now grieving during such an already stressful period", Amanda Hutcheson, the Brunswick County Government public information officer wrote in an email.
Federal and local officials have warned for days for residents in the storm's path in the Carolinas to make preparations for the hurricane and heed evacuation orders.
New Bern resident George Zaytoun chose not to evacuate and is trapped inside his home.
Peggy Perry, who was rescued by another group in New Bern, said rising water forced her into the upper level of her home.
North Carolina Governor, Roy Cooper, delivered a message to his state this morning. He said parts of the state had seen storm surges - the bulge of seawater pushed ashore by the hurricane - as high as 10 feet.
The centre of the eye of the hurricane made landfall in Wrightsville Beach, North Carolina, and was moving slowly westward just south of Wilmington.
Tornadoes are also possible in the eastern North Carolina area according to the NHC, as wind and rain impact land.
The storm has claimed at least five lives, two of them in Wilmington, NC. River flooding may be worse than Hurricane Floyd in 1999.
An estimated 10 to 15 inches of rain has already fallen in some areas of North Carolina and the heavy rain is expected to continue for days, with more than 40 inches believed to be possible. The storm is moving at a crawling speed - just 3 miles per hour.
Over 770,000 were without power in North Carolina Friday night.
As of 1 p.m. EDT, Florence is weakening as it moves farther inland over southeastern North Carolina. Six sheriff's officers came to his house to rescue him Friday morning, but he didn't need to leave since the water was dropping by then.