New Arsenal boss Unai Emery has a hard job on his hands replacing the legendary Arsene Wenger at the Emirates.
Claude Puel's men then head to Southampton, host Liverpool and travel south to face AFC Bournemouth before a home clash with Huddersfield Town completes their opening six games.
Our final pre-season fixture takes place just two days after the Community Shield, so you can expect a heavily rotated side.
Perhaps the most eagerly anticipated game next season will not be the Manchester derby, but the first clash between City and Liverpool at Anfield on October 6.
Absolutely, it is the game before the season starts.
Tottenham, who will join City, United and Liverpool in the Champions League next season, begin their campaign at Newcastle for the second successive season before hosting Fulham a week later.
The two sides will meet in pre-season at the Aviva stadium in Dublin, having played each other five times in three competitions in the 2017-18 season.