Samantha has made something of a cottage industry out of talking about her estranged sibling who, she admits, she hasn't seen since 2010 and has had one conversation with since then.
If you've been living under a rock, Samantha is the daughter of Thomas Markle, Meghan's father, who has been caught setting up paparazzi shots of himself for money.
Markle defended herself by declaring Morgan was just pulling her supposed statements from tabloids, which are "wholly inaccurate".
He continued: "You've spent the last two years criticizing her, you called her a narcissist, selfish, that Hollywood changed her and that Prince Harry shouldn't marry her, yet you have the gall to blame media vultures".
She also appeared to blame the media for causing Thomas to have a heart attack which has been claimed as the reason he won't be attending the wedding to walk Meghan down the aisle.
If he had been paid, she insisted, it would have been a "pittance".
Samantha has taken responsibility for making the arrangements and was on Good Morning Britain to defend her actions, describing the media as "vultures".
Samantha said she set up the photo shoot out of kindness "for the benefit of the royal family".
"The media was unfairly making him look bad so I suggested he do positive photos for his benefit and the benefit of the royal family".
She said he called her "panicking on the freeway because he was in a risky situation being followed by seven or eight cars".
Host Piers Morgan wasn't buying her story though and went on the offensive against Samantha. "I think a person has a right to say 'Enough is enough, '" Samantha said, before Piers interjected, "There's no bigger media vulture than you, is there, Ms. Markle?".
"You say this is all the media's fault, that he's not coming to the wedding because of this, because the media have been treating him in a shabby way".