"It is with deep regret that I have to withdraw from tomorrow's Boston Marathon", Hasay wrote.
On the eve of the 2018 marathon the mayor believes the tragedy has united the city.
Flanagan, victor of the Olympic silver medal in the 10,000 metres at Beijing 2008, was brought up outside Boston and has said that winning its marathon - first open to women in 1966 - remains her last big goal in running.
The women's field features American contenders Molly Huddle, Jordan Hasay, Desiree Linden and reigning New York City Marathon champion Shalane Flanagan.No US woman has won the Boston crown since Lisa Larsen Weidenbach in 1985, although Linden was second in 2011 and Hasay took third past year in her marathon debut as well as in Chicago.
Later that year, the former University of OR star followed with a third-place finish at the Chicago Marathon, with an improved time of 2:20:57.
For all the impact made by Hasey in recent months, she was soundly beaten over 15 kilometres recently by Molly Huddle.
The run will be noticeably different for him this year.
Hasay crushed the American record for a marathon debut by nearly three minutes at Boston a year ago.
The question will be how much longer Kiplagat, now 38, can maintain her winning form. Of her experience training for the marathon all while raising funds for FamilyAid Boston, she states: "This is also my very first marathon and I'm giving my all to help ensure I can cross that finish line".
"We support that decision and have invited Jordan to return to Boston next year".
More recently Rupp has become only the second USA runner to break the hour mark for the half-marathon. She was also second to Rose Chelimo in the World Track and Field Championships marathon and fourth in NY.