Pence had been scheduled to attend a banquet hosted by Peruvian President Martin Vizcarra on Friday night, and it was not immediately clear if he would still attend.
During that time, Latin America has seen turmoil in many countries related to corruption - including the resignation of Peru's previous president three weeks ago, the jailing of Brazil's former president a week ago, and increased scrutiny on Guatemala's current president by a UN-backed body.
The theme of the gathering is combatting corruption.
Luis Carlos Battista is a Cuban lawyer and political consultant.
An economic collapse in Venezuela is driving about 100,000 people per month to flee the country controlled by socialist President Nicolas Maduro.
The vice president says Maduro has turned Venezuela into a dictatorship and has brought about "abject misery".
That same day Trump tweeted that the USA would only join the CPTPP, a multinational trade deal his administration walked away from a year ago, if it offered "substantially better" terms than those provided under previous TPP negotiations. "Our message to Russian Federation is that you're on the wrong side of history", Pence said.
The U.S. has sanctioned Maduro and dozens of high officers, accusing the nation of human rights abuses.
Relations between the worldwide locations have additionally been strained amid mysterious sonic assaults that US diplomats in Havana stated have left them with illnesses together with complications, listening to issues and concussions.
The same position was expressed during national forums held in Cuba in preparation for the events in Lima.
Cuban President Raul Castro has joined a growing list of foreign leaders skipping the Summit of the Americas.
Pence is due to meet Latin American leaders at the regional Summit of the Americas in Peru, which starts on Friday. White House officials said the vice president would emphasize the U.S.as the "partner of choice" in Latin American trade, noting that almost half of the US trade agreements are based in the Western Hemisphere. The U.S. led a missile strike in Syria earlier Saturday.
"We are with you", Pence told the opposition leaders, in what he described as a message from Trump to the opposition and people of Venezuela.
Trump had lambasted the accord during his presidential campaign, and pulled the United States out of the deal shortly after taking office. That adds further tensions as the neighbors, along with Canada, work to renegotiate the North American Free Trade Agreement.
President Donald Trump has long assailed the impact of NAFTA on US workers and insisted on a new round of negotiations with Canada and Mexico on the deal.
At a business conference held in the run-up to the summit, political and business leaders affirmed the virtues of free trade and the need to develop deeper ties in the hemisphere to compete with Asian countries.
He said the Trans Pacific Partnership agreement is "an ambitious trade deal that puts people first".
Among the members of the USA delegation was Trump's daughter and adviser, Ivanka, who on Friday morning announced a new $150 million US initiative to help women in Latin America access credit for businesses.
President Donald Trump promised to build a wall along the southern border and insisted Mexico would pay for it. Mexico has refused.
The senators encourage Trump to drop an "America First" policy they say is divisive "and embrace instead an "Americas together" policy". The letter blames those policies for declining support for the U.S.in the region at a time China and Russian Federation are making important inroads.