Karachi successfully hosted the Pakistan Super League final last weekend, and the visit of the Windies represents the next step for the country in its bid to host regular global cricket for the first time since a terrorist attack on the Sri Lankan team bus in Lahore in 2009.
The International Cricket Council (ICC) match referee David Boon will supervise the series while ICC general manager cricket Geoff Allardice and umpires' manager Adrian Griffith will also attend the matches to oversee arrangements.
Cricket West Indies has delayed the announcement of its squad for the tour to Pakistan due to unavailability of key players.
Since then, Pakistan have played their home fixtures in the United Arab Emirates, but a World XI arrived for three T20s in September, a month before Sri Lanka flew to Lahore for a T20 that concluded their three-match rubber.
"We saw a big crowd in the PSL final so I hope they will come in big numbers for the Twenty20 series", he said.
"We have made it very clear to the players and support staff that had personal reservations about this tour that we fully understand and accept their position".
He is fresh off the ICC World Cup qualifiers in Zimbabwe where he served as vice-captain on the ODI side but featured in only two matches.
Players underwent three-hours long nets session under the supervision of head coach Mickey Arthur, who kept a close eye on youngsters included in the squad.
Jamaica batsman Andre McCarthy and fast bowler Odean Smith will make the senior debuts.
West Indies selectors on Thursday belatedly named a 13-man second string squad for the historic three-match Twenty20 tour of Pakistan, with several of the leading stars opting out because of security concerns.
There has also been a recall to worldwide cricket for wicketkeeper Denesh Ramdin, who last played in the shortest format for the Windies when they won the World T20 in 2016.
"Denesh brings a lot of experience and an opportunity to restart his worldwide career", Browne said.
The Calypsos roster, led by Jason Mohammed, will feature batsmen Marlon Samuels and Andre Fletcher, who contributed to the success of Peshawar Zalmi with hard-hitting knocks in the recently concluded Pakistan Super League (PSL) 2018.