Trump asked Tillerson to resign on Friday, according to the Washington Post. The secretary cut short his diplomatic trip to Africa, returning to Washington, DC, on Monday.
Tillerson is the former ExxonMobil CEO.
Last week, Trump's chief economic advisor Gary Cohn resigned after the president announced he would impose tariffs on steel and aluminum imports.
Gina Haspel, the Deputy Director of the Central Intelligence Agency, will be nominated to replace Director Pompeo and she will be the CIA's first-ever female director, a historic milestone.
In 2010, Pompeo defeated State Senator Jean Schodorf for the Kansas Republican primary for the 4th District Congressional seat. She will be the first woman to take that role. The GOP holds a 52-48 margin in the Senate. In October, NBC reported that Tillerson called the president a "moron" following a meeting in July. He is a former member of the Boy Scouts of America Executive Committee and served as national president of the Boy Scouts from 2010 to 2012.