Each of the last two years the Tigers won their first-round game on the bracket and lost to the host team in the second round, Texas in 2016 and Florida State in 2017.
Overall, the Noles have made 16 appearances in March Madness, last making the Sweet 16 in 2011.
Xavier is a No. 1 seed for the first time, earned by winning the Big East.
Like Missouri, Florida State (20-11) won 20 games this season. This team has already reached what most fans would say was their number one goal before the season, they've made the dance.
The Noles scored 90 or more points nine times this year, and have three players - Phil Cofer, Terance Mann and Braian Angola-Rodas - averaging around 13 points per game. In that game, Missouri forward Jontay Porter put up 20 points. Missouri is ranked No. 38 on KenPom, where Florida State is ranked No. 35.
Here are 5 things to know about the Seminoles. He can travel and practice to Nashville. All of that makes it the best case scenario for Missouri as a No. 8 seed. We've managed to get to this point. Barnett, arrested Saturday morning in Columbia for a DWI, has officially been suspended for the first game of the NCAA Tournament, Cuonzo Martin told reporters at a post Selection Show press conference. Barnett will be available if they advance.
With Barnett's suspension, Missouri is now down to only seven scholarship players.
We will find out by Friday night.
Over on the Missouri side, they're now 20-12 this year.