You will never be vice president. "You're too mean and unrelatable". "If all voters care about is whether somebody puts on a good show, we'll just come up with a celebrity of our own".
Winfrey burst into laughter.
Missed the ceremony? Fear not, as we have summed all the major talking points below, ranging from Natalie Portman's quick dig at the all-male director nominees to Oprah's magnificent speech.
Without mentioning President Trump by name, she talked about a "new day" in Hollywood with women being empowered.
She brought the crowd at the Beverly Hilton to its feet.
Ever outspoken in speeches and social media, she stayed away from partisanship.
Her best friend, Gayle King, told the outlet: "I thought that speech was incredible".
"Look, it's ridiculous - and I get that".
Janney, who won for her role in "I, Tonya", said hearing Winfrey's speech made her cry and gave her "chills".
On the other hand, I could argue that she should be disqualified simply on the basis of her promotion of "The Secret", a multimedia juggernaut that claimed that the entire universe and every moment of human experience are governed by "the law of attraction".
Accepting her award, McDormand granted she was befuddled at the identities of the Hollywood Foreign Press Association, but gave them credit. "Okaay!" she reportedly responded.
Greta Gerwig, whose directorial debut Lady Bird was named best musical or comedy film, could be seen being hugged by her film's star, Saoirse Ronan, as Streisand made her comments. And the "Oprah for president?" possibility was a top story on morning TV. They're weirdly powerful, people pay attention against what is sometimes their better judgment, and if you can seize the moment in which the spotlight settles on you, you might get something done.
In the past, Winfrey has definitely shut down the suggestion. Brown, the first black man to win the category, thanked "This Is Us" creator Dan Fogelman.
In September, columnist John Podhoretz wrote in the New York Post that Winfrey is "uniquely positioned, should she wish to commit herself, to seek the Democratic nomination for president and challenge Trump in 2020".
In a March interview with Bloomberg TV's David Rubenstein asked Winfrey about her 2020 plans.
This was as a result of discriminatory legislation, collectively known as the "Jim Crow" laws, which segregated black people and white people in public spaces and strengthened discriminatory attitudes.
"And here are all the male nominees", she said, introducing Christopher Nolan (Dunkirk), Martin McDonagh (Three Billboards Outside Ebbing, Missouri), Steven Spielberg (The Post), Ridley Scott (All the Money in the World) and eventual victor, The Shape of Water filmmaker Guillermo del Toro.
Some of Winfrey's confidants have been privately urging her to run, the sources said.
The first award of the night, perhaps fittingly, went to one of Hollywood's most powerful women: Nicole Kidman, for her performance in HBO's "The Big Little Lies", a series she and Reese Witherspoon also produced.
Although a TV star winning the presidency hasn't worked out that well so far, people are very serious about wanting the The Color Purple actress to take over the White House. And connecting an uber-popular name like "Oprah" with "presidential campaign" is naturally going to generate loads of excitement.
Then there's her popularity. Mr. Trump had a 61 percent unfavorable score in Gallup's November 2016 poll just before the election.